Humber, 30, originally signed on with the Colts as an undrafted free agent out of North Dakota State back in 2009. He lasted just over a year in Indianapolis before signing on with the Saints during the 2012 season.
Humber was in the final year of his two-year, $2.085 million contract when he was cut loose last year. The Patriots later signed him, but elected to release as they cut their roster down to 75 players.
The Bills signed him to a contract soon after and brought him back on a one-year, $900,000 deal this past February.
In 2017, Humber has appeared in four games and recorded 37 tackles, no sacks and a pass defense for the Bills.