The Bills signed first-round DE Gregory Rousseau to a four-year rookie contract, according to Adam Schefter.
Buffalo has now signed all but one of their eight draft picks:
| Round | Player | Pos. | Note |
| 1 | Gregory Rousseau | EDGE | Signed |
| 2 | Carlos Basham | DL | Signed |
| 3 | Spencer Brown | OL | |
| 5 | Tommy Doyle | OT | Signed |
| 6 | Marquez Stevenson | WR | Signed |
| 6 | Damar Hamlin | DB | Signed |
| 6 | Rachad Wildgoose | CB | Signed |
| 7 | Jack Anderson | G | Signed |
Rousseau, 21, was a one-year starter at Miami, and was named to second-team All-American, ACC Defensive Rookie of the Year, and first team All-ACC. He chose to opt out of the 2020 season.
Rousseau is projected to sign a four-year, $11,608,200 with the Bills that includes a $5,802,327 signing bonus. The Bills will have a fifth-year option to pick up on him in 2024.
During his college career at Miami, Rousseau recorded 59 tackles, 15.5 sacks, two forced fumbles, and one pass defended.
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