If the injury keeps Campbell out for the rest of the season, it will be the second season-ending injury in as many seasons for the 2019 second-round pick.
Campbell had appeared in two games for Indianapolis and caught six passes for 71 yards this season.
Campbell, 23, was drafted by the Colts in the second round out of Ohio State during the 2019 NFL Draft. He signed a four-year rookie deal worth $4.7 million with $2.7 million guaranteed.
In 2019, Campbell appeared in seven games for the Colts and caught 18 passes for 127 yards and a touchdown. He also carried the ball four times for 34 yards and totaled 175 kickoff return yards.