According to Schefter, it’s possible the Bills will also be without veteran RB Chris Ivory, who will be a game-time decision with a shoulder injury.
In the event Ivory is unable to play, the Bills would turn to Keith Ford and Marcus Murphy as their top-two running backs.
McCoy actually came up in trade rumors leading up to this year’s deadline, but Buffalo elected to hold on to him.
McCoy, 30, is a former second-round pick of the Eagles back in 2009. After six years in Philadelphia, McCoy was traded to the Bills, who later signed him to a five-year, $40 million contract that included $20 million guaranteed.
McCoy stands to make base salaries of $6 million and $6.075 million over the next two years of the agreement.
In 2018, McCoy has appeared in 12 games for the Bills and rushed for 479 yards on 145 carries (3.3 YPC) to go along with 29 receptions for 210 yards receiving and two touchdowns.
Ivory, 30, originally signed on with the Saints as an undrafted free agent back in 2010. He spent three years in New Orleans before he was traded to the Jets for a fourth-round pick.
Ivory signed a five-year, $32 million contract that included $10 million guaranteed with the Jaguars back in 2016, but lasted just two years in Jacksonville before he was released this past February.
The Bills later signed Ivory to a two-year contract worth $5.5 million.
In 2018, Ivory has appeared in 12 games for the Bills and rushed for 340 yards on 101 carries (3.4 YPC) to go along with 12 receptions for 159 yards receiving and one touchdown.