ESPN’s Jeremy Fowler reports the 49ers are placing RB Isaac Guerendo on the reserve/PUP list with a pec injury, sidelining him for the first four games of the season.
Guerendo, 26, was a third-round pick by the 49ers out of Louisville in the 2024 NFL Draft. He signed a four-year, $4,724,528 rookie deal with a base salary of $1,075,000 in 2026.
In 2025, Guerendo appeared in 14 games for the 49ers.
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