The Titans also waived OL Patrick Morris.
Dupree, 28, is a former first-round pick out of Kentucky by the Steelers in the 2015 NFL Draft. He was in the final year of a four-year, $9.22 million rookie contract when the Steelers picked up his fifth-year option that paid him $9,232,000 for the 2019 season.
From there, the Steelers opted to franchise Dupree last year and he later signed a five-year deal worth up to $85 million this offseason.
In 2020, Dupree appeared in 11 games for the Steelers and recorded 31 tackles, eight sacks, two forced fumbles and two passes defended.